Synthesis and biological properties of benzo-annulated rutaecarpines.
نویسندگان
چکیده
A series of benzo-annulated rutaecarpines were prepared from anthranilic acid and 3-aminonaphthalene-2-carboxylic acid by Fischer indole synthesis as key reaction. Cytotoxicity was somewhat increased by the introduction of benzo-annulation, which was not directly related to the inhibitory activity against topoisomerases (topo) I and II. Benzo-annulation on ring A led to significant increase of inhibitory activity against topo II while annulations on ring E increased inhibitory activity against topo I.
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ورودعنوان ژورنال:
- Biological & pharmaceutical bulletin
دوره 33 10 شماره
صفحات -
تاریخ انتشار 2010